Diabetes-associated alterations in the cecal microbiome and metabolome are independent of diet or environment in the UC Davis Type 2 Diabetes Mellitus Rat model.
Identifieur interne : 000274 ( Main/Exploration ); précédent : 000273; suivant : 000275Diabetes-associated alterations in the cecal microbiome and metabolome are independent of diet or environment in the UC Davis Type 2 Diabetes Mellitus Rat model.
Auteurs : Brian D. Piccolo [États-Unis] ; James L. Graham [États-Unis] ; Kimber L. Stanhope [États-Unis] ; Intawat Nookaew [États-Unis] ; Kelly E. Mercer [États-Unis] ; Sree V. Chintapalli [États-Unis] ; Umesh D. Wankhade [États-Unis] ; Kartik Shankar [États-Unis] ; Peter J. Havel [États-Unis] ; Sean H. Adams [États-Unis]Source :
- American journal of physiology. Endocrinology and metabolism [ 1522-1555 ] ; 2018.
Descripteurs français
- KwdFr :
- Animaux (MeSH), Bacteroides (isolement et purification), Caecum (microbiologie), Caecum (métabolisme), Diabète de type 2 (microbiologie), Diabète de type 2 (métabolisme), Firmicutes (isolement et purification), Microbiome gastro-intestinal (physiologie), Modèles animaux de maladie humaine (MeSH), Mâle (MeSH), Métabolome (MeSH), Métabolomique (MeSH), Métagénomique (MeSH), Rat Sprague-Dawley (MeSH), Rats (MeSH), Régime alimentaire (MeSH), État prédiabétique (microbiologie), État prédiabétique (métabolisme).
- MESH :
- isolement et purification : Bacteroides, Firmicutes.
- microbiologie : Caecum, Diabète de type 2, État prédiabétique.
- métabolisme : Caecum, Diabète de type 2, État prédiabétique.
- physiologie : Microbiome gastro-intestinal.
- Animaux, Modèles animaux de maladie humaine, Mâle, Métabolome, Métabolomique, Métagénomique, Rat Sprague-Dawley, Rats, Régime alimentaire.
English descriptors
- KwdEn :
- Animals (MeSH), Bacteroides (isolation & purification), Cecum (metabolism), Cecum (microbiology), Diabetes Mellitus, Type 2 (metabolism), Diabetes Mellitus, Type 2 (microbiology), Diet (MeSH), Disease Models, Animal (MeSH), Firmicutes (isolation & purification), Gastrointestinal Microbiome (physiology), Male (MeSH), Metabolome (MeSH), Metabolomics (MeSH), Metagenomics (MeSH), Prediabetic State (metabolism), Prediabetic State (microbiology), Rats (MeSH), Rats, Sprague-Dawley (MeSH).
- MESH :
- isolation & purification : Bacteroides, Firmicutes.
- metabolism : Cecum, Diabetes Mellitus, Type 2, Prediabetic State.
- microbiology : Cecum, Diabetes Mellitus, Type 2, Prediabetic State.
- physiology : Gastrointestinal Microbiome.
- Animals, Diet, Disease Models, Animal, Male, Metabolome, Metabolomics, Metagenomics, Rats, Rats, Sprague-Dawley.
Abstract
The composition of the gut microbiome is altered in obesity and type 2 diabetes; however, it is not known whether these alterations are mediated by dietary factors or related to declines in metabolic health. To address this, cecal contents were collected from age-matched, chow-fed male University of California, Davis Type 2 Diabetes Mellitus (UCD-T2DM) rats before the onset of diabetes (prediabetic PD; n = 15), 2 wk recently diabetic (RD; n = 10), 3 mo (D3M; n = 11), and 6 mo (D6M; n = 8) postonset of diabetes. Bacterial species and functional gene counts were assessed by shotgun metagenomic sequencing of bacterial DNA in cecal contents, while metabolites were identified by gas chromatography-quadrupole time-off-flight-mass spectrometry. Metagenomic analysis showed a shift from Firmicutes species in early stages of diabetes (PD + RD) toward an enrichment of Bacteroidetes species in later stages of diabetes (D3M + D6M). In total, 45 bacterial species discriminated early and late stages of diabetes with 25 of these belonging to either Bacteroides or Prevotella genera. Furthermore, 61 bacterial gene clusters discriminated early and later stages of diabetes with elevations of enzymes related to stress response (e.g., glutathione and glutaredoxin) and amino acid, carbohydrate, and bacterial cell wall metabolism. Twenty-five cecal metabolites discriminated early vs. late stages of diabetes, with the largest differences observed in abundances of dehydroabietic acid and phosphate. Alterations in the gut microbiota and cecal metabolome track diabetes progression in UCD-T2DM rats when controlling for diet, age, and housing environment. Results suggest that diabetes-specific host signals impact the ecology and end product metabolites of the gut microbiome when diet is held constant.
DOI: 10.1152/ajpendo.00203.2018
PubMed: 30016149
PubMed Central: PMC6293161
Affiliations:
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Piccolo</name><affiliation wicri:level="2"><nlm:affiliation>Arkansas Children's Nutrition Center , Little Rock, Arkansas.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Arkansas</region></placeName><wicri:cityArea>Arkansas Children's Nutrition Center , Little Rock</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:affiliation>Department of Pediatrics, University of Arkansas for Medical Science , Little Rock, Arkansas.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Arkansas</region></placeName><wicri:cityArea>Department of Pediatrics, University of Arkansas for Medical Science , Little Rock</wicri:cityArea></affiliation></author><author><name sortKey="Graham, James L" sort="Graham, James L" uniqKey="Graham J" first="James L" last="Graham">James L. Graham</name><affiliation wicri:level="2"><nlm:affiliation>Department of Molecular Biosciences, School of Veterinary Medicine, University of California , Davis, California.</nlm:affiliation><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Department of Molecular Biosciences, School of Veterinary Medicine, University of California , Davis</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:affiliation>Department of Nutrition, University of California , Davis, California.</nlm:affiliation><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Department of Nutrition, University of California , Davis</wicri:cityArea></affiliation></author><author><name sortKey="Stanhope, Kimber L" sort="Stanhope, Kimber L" uniqKey="Stanhope K" first="Kimber L" last="Stanhope">Kimber L. Stanhope</name><affiliation wicri:level="2"><nlm:affiliation>Department of Molecular Biosciences, School of Veterinary Medicine, University of California , Davis, California.</nlm:affiliation><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Department of Molecular Biosciences, School of Veterinary Medicine, University of California , Davis</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:affiliation>Department of Nutrition, University of California , Davis, California.</nlm:affiliation><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Department of Nutrition, University of California , Davis</wicri:cityArea></affiliation></author><author><name sortKey="Nookaew, Intawat" sort="Nookaew, Intawat" uniqKey="Nookaew I" first="Intawat" last="Nookaew">Intawat Nookaew</name><affiliation wicri:level="2"><nlm:affiliation>Department of Biomedical Informatics, University of Arkansas for Medical Sciences , Little Rock, Arkansas.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Arkansas</region></placeName><wicri:cityArea>Department of Biomedical Informatics, University of Arkansas for Medical Sciences , Little Rock</wicri:cityArea></affiliation></author><author><name sortKey="Mercer, Kelly E" sort="Mercer, Kelly E" uniqKey="Mercer K" first="Kelly E" last="Mercer">Kelly E. Mercer</name><affiliation wicri:level="2"><nlm:affiliation>Arkansas Children's Nutrition Center , Little Rock, Arkansas.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Arkansas</region></placeName><wicri:cityArea>Arkansas Children's Nutrition Center , Little Rock</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:affiliation>Department of Pediatrics, University of Arkansas for Medical Science , Little Rock, Arkansas.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Arkansas</region></placeName><wicri:cityArea>Department of Pediatrics, University of Arkansas for Medical Science , Little Rock</wicri:cityArea></affiliation></author><author><name sortKey="Chintapalli, Sree V" sort="Chintapalli, Sree V" uniqKey="Chintapalli S" first="Sree V" last="Chintapalli">Sree V. Chintapalli</name><affiliation wicri:level="2"><nlm:affiliation>Arkansas Children's Nutrition Center , Little Rock, Arkansas.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Arkansas</region></placeName><wicri:cityArea>Arkansas Children's Nutrition Center , Little Rock</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:affiliation>Department of Pediatrics, University of Arkansas for Medical Science , Little Rock, Arkansas.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Arkansas</region></placeName><wicri:cityArea>Department of Pediatrics, University of Arkansas for Medical Science , Little Rock</wicri:cityArea></affiliation></author><author><name sortKey="Wankhade, Umesh D" sort="Wankhade, Umesh D" uniqKey="Wankhade U" first="Umesh D" last="Wankhade">Umesh D. Wankhade</name><affiliation wicri:level="2"><nlm:affiliation>Arkansas Children's Nutrition Center , Little Rock, Arkansas.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Arkansas</region></placeName><wicri:cityArea>Arkansas Children's Nutrition Center , Little Rock</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:affiliation>Department of Pediatrics, University of Arkansas for Medical Science , Little Rock, Arkansas.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Arkansas</region></placeName><wicri:cityArea>Department of Pediatrics, University of Arkansas for Medical Science , Little Rock</wicri:cityArea></affiliation></author><author><name sortKey="Shankar, Kartik" sort="Shankar, Kartik" uniqKey="Shankar K" first="Kartik" last="Shankar">Kartik Shankar</name><affiliation wicri:level="2"><nlm:affiliation>Arkansas Children's Nutrition Center , Little Rock, Arkansas.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Arkansas</region></placeName><wicri:cityArea>Arkansas Children's Nutrition Center , Little Rock</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:affiliation>Department of Pediatrics, University of Arkansas for Medical Science , Little Rock, Arkansas.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Arkansas</region></placeName><wicri:cityArea>Department of Pediatrics, University of Arkansas for Medical Science , Little Rock</wicri:cityArea></affiliation></author><author><name sortKey="Havel, Peter J" sort="Havel, Peter J" uniqKey="Havel P" first="Peter J" last="Havel">Peter J. Havel</name><affiliation wicri:level="2"><nlm:affiliation>Department of Molecular Biosciences, School of Veterinary Medicine, University of California , Davis, California.</nlm:affiliation><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Department of Molecular Biosciences, School of Veterinary Medicine, University of California , Davis</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:affiliation>Department of Nutrition, University of California , Davis, California.</nlm:affiliation><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Department of Nutrition, University of California , Davis</wicri:cityArea></affiliation></author><author><name sortKey="Adams, Sean H" sort="Adams, Sean H" uniqKey="Adams S" first="Sean H" last="Adams">Sean H. Adams</name><affiliation wicri:level="2"><nlm:affiliation>Arkansas Children's Nutrition Center , Little Rock, Arkansas.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Arkansas</region></placeName><wicri:cityArea>Arkansas Children's Nutrition Center , Little Rock</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:affiliation>Department of Pediatrics, University of Arkansas for Medical Science , Little Rock, Arkansas.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Arkansas</region></placeName><wicri:cityArea>Department of Pediatrics, University of Arkansas for Medical Science , Little Rock</wicri:cityArea></affiliation></author></analytic><series><title level="j">American journal of physiology. Endocrinology and metabolism</title><idno type="eISSN">1522-1555</idno><imprint><date when="2018" type="published">2018</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals (MeSH)</term><term>Bacteroides (isolation & purification)</term><term>Cecum (metabolism)</term><term>Cecum (microbiology)</term><term>Diabetes Mellitus, Type 2 (metabolism)</term><term>Diabetes Mellitus, Type 2 (microbiology)</term><term>Diet (MeSH)</term><term>Disease Models, Animal (MeSH)</term><term>Firmicutes (isolation & purification)</term><term>Gastrointestinal Microbiome (physiology)</term><term>Male (MeSH)</term><term>Metabolome (MeSH)</term><term>Metabolomics (MeSH)</term><term>Metagenomics (MeSH)</term><term>Prediabetic State (metabolism)</term><term>Prediabetic State (microbiology)</term><term>Rats (MeSH)</term><term>Rats, Sprague-Dawley (MeSH)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux (MeSH)</term><term>Bacteroides (isolement et purification)</term><term>Caecum (microbiologie)</term><term>Caecum (métabolisme)</term><term>Diabète de type 2 (microbiologie)</term><term>Diabète de type 2 (métabolisme)</term><term>Firmicutes (isolement et purification)</term><term>Microbiome gastro-intestinal (physiologie)</term><term>Modèles animaux de maladie humaine (MeSH)</term><term>Mâle (MeSH)</term><term>Métabolome (MeSH)</term><term>Métabolomique (MeSH)</term><term>Métagénomique (MeSH)</term><term>Rat Sprague-Dawley (MeSH)</term><term>Rats (MeSH)</term><term>Régime alimentaire (MeSH)</term><term>État prédiabétique (microbiologie)</term><term>État prédiabétique (métabolisme)</term></keywords><keywords scheme="MESH" qualifier="isolation & purification" xml:lang="en"><term>Bacteroides</term><term>Firmicutes</term></keywords><keywords scheme="MESH" qualifier="isolement et purification" xml:lang="fr"><term>Bacteroides</term><term>Firmicutes</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Cecum</term><term>Diabetes Mellitus, Type 2</term><term>Prediabetic State</term></keywords><keywords scheme="MESH" qualifier="microbiologie" xml:lang="fr"><term>Caecum</term><term>Diabète de type 2</term><term>État prédiabétique</term></keywords><keywords scheme="MESH" qualifier="microbiology" xml:lang="en"><term>Cecum</term><term>Diabetes Mellitus, Type 2</term><term>Prediabetic State</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Caecum</term><term>Diabète de type 2</term><term>État prédiabétique</term></keywords><keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Microbiome gastro-intestinal</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Gastrointestinal Microbiome</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Diet</term><term>Disease Models, Animal</term><term>Male</term><term>Metabolome</term><term>Metabolomics</term><term>Metagenomics</term><term>Rats</term><term>Rats, Sprague-Dawley</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Modèles animaux de maladie humaine</term><term>Mâle</term><term>Métabolome</term><term>Métabolomique</term><term>Métagénomique</term><term>Rat Sprague-Dawley</term><term>Rats</term><term>Régime alimentaire</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The composition of the gut microbiome is altered in obesity and type 2 diabetes; however, it is not known whether these alterations are mediated by dietary factors or related to declines in metabolic health. To address this, cecal contents were collected from age-matched, chow-fed male University of California, Davis Type 2 Diabetes Mellitus (UCD-T2DM) rats before the onset of diabetes (prediabetic PD; n = 15), 2 wk recently diabetic (RD; n = 10), 3 mo (D3M; n = 11), and 6 mo (D6M; n = 8) postonset of diabetes. Bacterial species and functional gene counts were assessed by shotgun metagenomic sequencing of bacterial DNA in cecal contents, while metabolites were identified by gas chromatography-quadrupole time-off-flight-mass spectrometry. Metagenomic analysis showed a shift from Firmicutes species in early stages of diabetes (PD + RD) toward an enrichment of Bacteroidetes species in later stages of diabetes (D3M + D6M). In total, 45 bacterial species discriminated early and late stages of diabetes with 25 of these belonging to either Bacteroides or Prevotella genera. Furthermore, 61 bacterial gene clusters discriminated early and later stages of diabetes with elevations of enzymes related to stress response (e.g., glutathione and glutaredoxin) and amino acid, carbohydrate, and bacterial cell wall metabolism. Twenty-five cecal metabolites discriminated early vs. late stages of diabetes, with the largest differences observed in abundances of dehydroabietic acid and phosphate. Alterations in the gut microbiota and cecal metabolome track diabetes progression in UCD-T2DM rats when controlling for diet, age, and housing environment. Results suggest that diabetes-specific host signals impact the ecology and end product metabolites of the gut microbiome when diet is held constant.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">30016149</PMID><DateCompleted><Year>2019</Year><Month>08</Month><Day>26</Day></DateCompleted><DateRevised><Year>2020</Year><Month>03</Month><Day>06</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1522-1555</ISSN><JournalIssue CitedMedium="Internet"><Volume>315</Volume><Issue>5</Issue><PubDate><Year>2018</Year><Month>11</Month><Day>01</Day></PubDate></JournalIssue><Title>American journal of physiology. Endocrinology and metabolism</Title><ISOAbbreviation>Am J Physiol Endocrinol Metab</ISOAbbreviation></Journal><ArticleTitle>Diabetes-associated alterations in the cecal microbiome and metabolome are independent of diet or environment in the UC Davis Type 2 Diabetes Mellitus Rat model.</ArticleTitle><Pagination><MedlinePgn>E961-E972</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1152/ajpendo.00203.2018</ELocationID><Abstract><AbstractText>The composition of the gut microbiome is altered in obesity and type 2 diabetes; however, it is not known whether these alterations are mediated by dietary factors or related to declines in metabolic health. To address this, cecal contents were collected from age-matched, chow-fed male University of California, Davis Type 2 Diabetes Mellitus (UCD-T2DM) rats before the onset of diabetes (prediabetic PD; n = 15), 2 wk recently diabetic (RD; n = 10), 3 mo (D3M; n = 11), and 6 mo (D6M; n = 8) postonset of diabetes. Bacterial species and functional gene counts were assessed by shotgun metagenomic sequencing of bacterial DNA in cecal contents, while metabolites were identified by gas chromatography-quadrupole time-off-flight-mass spectrometry. Metagenomic analysis showed a shift from Firmicutes species in early stages of diabetes (PD + RD) toward an enrichment of Bacteroidetes species in later stages of diabetes (D3M + D6M). In total, 45 bacterial species discriminated early and late stages of diabetes with 25 of these belonging to either Bacteroides or Prevotella genera. Furthermore, 61 bacterial gene clusters discriminated early and later stages of diabetes with elevations of enzymes related to stress response (e.g., glutathione and glutaredoxin) and amino acid, carbohydrate, and bacterial cell wall metabolism. Twenty-five cecal metabolites discriminated early vs. late stages of diabetes, with the largest differences observed in abundances of dehydroabietic acid and phosphate. Alterations in the gut microbiota and cecal metabolome track diabetes progression in UCD-T2DM rats when controlling for diet, age, and housing environment. Results suggest that diabetes-specific host signals impact the ecology and end product metabolites of the gut microbiome when diet is held constant.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Piccolo</LastName><ForeName>Brian D</ForeName><Initials>BD</Initials><AffiliationInfo><Affiliation>Arkansas Children's Nutrition Center , Little Rock, Arkansas.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Pediatrics, University of Arkansas for Medical Science , Little Rock, Arkansas.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Graham</LastName><ForeName>James L</ForeName><Initials>JL</Initials><AffiliationInfo><Affiliation>Department of Molecular Biosciences, School of Veterinary Medicine, University of California , Davis, California.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Nutrition, University of California , Davis, California.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Stanhope</LastName><ForeName>Kimber L</ForeName><Initials>KL</Initials><AffiliationInfo><Affiliation>Department of Molecular Biosciences, School of Veterinary Medicine, University of California , Davis, California.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Nutrition, University of California , Davis, California.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Nookaew</LastName><ForeName>Intawat</ForeName><Initials>I</Initials><AffiliationInfo><Affiliation>Department of Biomedical Informatics, University of Arkansas for Medical Sciences , Little Rock, Arkansas.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mercer</LastName><ForeName>Kelly E</ForeName><Initials>KE</Initials><AffiliationInfo><Affiliation>Arkansas Children's Nutrition Center , Little Rock, Arkansas.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Pediatrics, University of Arkansas for Medical Science , Little Rock, Arkansas.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chintapalli</LastName><ForeName>Sree V</ForeName><Initials>SV</Initials><AffiliationInfo><Affiliation>Arkansas Children's Nutrition Center , Little Rock, Arkansas.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Pediatrics, University of Arkansas for Medical Science , Little Rock, Arkansas.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wankhade</LastName><ForeName>Umesh D</ForeName><Initials>UD</Initials><AffiliationInfo><Affiliation>Arkansas Children's Nutrition Center , Little Rock, Arkansas.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Pediatrics, University of Arkansas for Medical Science , Little Rock, Arkansas.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Shankar</LastName><ForeName>Kartik</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Arkansas Children's Nutrition Center , Little Rock, Arkansas.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Pediatrics, University of Arkansas for Medical Science , Little Rock, Arkansas.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Havel</LastName><ForeName>Peter J</ForeName><Initials>PJ</Initials><AffiliationInfo><Affiliation>Department of Molecular Biosciences, School of Veterinary Medicine, University of California , Davis, California.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Nutrition, University of California , Davis, California.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Adams</LastName><ForeName>Sean H</ForeName><Initials>SH</Initials><AffiliationInfo><Affiliation>Arkansas Children's Nutrition Center , Little Rock, Arkansas.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Pediatrics, University of Arkansas for Medical Science , Little Rock, Arkansas.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>R01 DK050603</GrantID><Acronym>NIDDK NIH HHS</Acronym><Agency>National Institute of Diabetes and Digestive and Kidney Diseases</Agency><Country>United States</Country></Grant><Grant><GrantID>P20 GM125503</GrantID><Acronym>GM</Acronym><Agency>NIGMS NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R01 DK078328</GrantID><Acronym>NIDDK NIH HHS</Acronym><Agency>National Institute of Diabetes and Digestive and Kidney Diseases</Agency><Country>United States</Country></Grant><Grant><GrantID>R01 HL121324</GrantID><Acronym>NHLBI NIH HHS</Acronym><Agency>National Heart, Lung, and Blood Institute</Agency><Country>United States</Country></Grant><Grant><GrantID>P20 GM121293</GrantID><Acronym>NIGMS NIH HHS</Acronym><Agency>National Institute of General Medical Sciences</Agency><Country>United States</Country></Grant><Grant><GrantID>R01 HL107256</GrantID><Acronym>NHLBI NIH HHS</Acronym><Agency>National Heart, Lung, and Blood Institute</Agency><Country>United States</Country></Grant><Grant><GrantID>R01 HL091333</GrantID><Acronym>NHLBI NIH HHS</Acronym><Agency>National Heart, Lung, and Blood Institute</Agency><Country>United States</Country></Grant><Grant><GrantID>P20 GM125503</GrantID><Acronym>NIGMS NIH HHS</Acronym><Agency>National Institute of General Medical Sciences</Agency><Country>United States</Country></Grant><Grant><GrantID>U24 DK092993</GrantID><Acronym>NIDDK NIH HHS</Acronym><Agency>National Institute of Diabetes and Digestive and Kidney Diseases</Agency><Country>United States</Country></Grant><Grant><GrantID>RC1 DK087307</GrantID><Acronym>NIDDK NIH HHS</Acronym><Agency>National Institute of Diabetes and Digestive and Kidney Diseases</Agency><Country>United States</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D052061">Research Support, N.I.H., Extramural</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType><PublicationType UI="D013486">Research Support, U.S. Gov't, Non-P.H.S.</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2018</Year><Month>07</Month><Day>17</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Am J Physiol Endocrinol Metab</MedlineTA><NlmUniqueID>100901226</NlmUniqueID><ISSNLinking>0193-1849</ISSNLinking></MedlineJournalInfo><MeshHeadingList><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D001439" MajorTopicYN="N">Bacteroides</DescriptorName><QualifierName UI="Q000302" MajorTopicYN="N">isolation & purification</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D002432" MajorTopicYN="N">Cecum</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName><QualifierName UI="Q000382" MajorTopicYN="Y">microbiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D003924" MajorTopicYN="N">Diabetes Mellitus, Type 2</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName><QualifierName UI="Q000382" MajorTopicYN="Y">microbiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D004032" MajorTopicYN="N">Diet</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D004195" MajorTopicYN="N">Disease Models, Animal</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000068536" MajorTopicYN="N">Firmicutes</DescriptorName><QualifierName UI="Q000302" MajorTopicYN="N">isolation & purification</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000069196" MajorTopicYN="N">Gastrointestinal Microbiome</DescriptorName><QualifierName UI="Q000502" MajorTopicYN="Y">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D055442" MajorTopicYN="Y">Metabolome</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D055432" MajorTopicYN="N">Metabolomics</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D056186" MajorTopicYN="N">Metagenomics</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011236" MajorTopicYN="N">Prediabetic State</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName><QualifierName UI="Q000382" MajorTopicYN="Y">microbiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D051381" MajorTopicYN="N">Rats</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D017207" MajorTopicYN="N">Rats, Sprague-Dawley</DescriptorName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="Y">diabetes</Keyword><Keyword MajorTopicYN="Y">metabolomics</Keyword><Keyword MajorTopicYN="Y">metagenomics</Keyword><Keyword MajorTopicYN="Y">microbiota</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2018</Year><Month>7</Month><Day>18</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2019</Year><Month>8</Month><Day>27</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2018</Year><Month>7</Month><Day>18</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">30016149</ArticleId><ArticleId IdType="doi">10.1152/ajpendo.00203.2018</ArticleId><ArticleId 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IdType="pubmed">27094034</ArticleId></ArticleIdList></Reference></ReferenceList></PubmedData></pubmed><affiliations><list><country><li>États-Unis</li></country><region><li>Arkansas</li><li>Californie</li></region></list><tree><country name="États-Unis"><region name="Arkansas"><name sortKey="Piccolo, Brian D" sort="Piccolo, Brian D" uniqKey="Piccolo B" first="Brian D" last="Piccolo">Brian D. Piccolo</name></region><name sortKey="Adams, Sean H" sort="Adams, Sean H" uniqKey="Adams S" first="Sean H" last="Adams">Sean H. Adams</name><name sortKey="Adams, Sean H" sort="Adams, Sean H" uniqKey="Adams S" first="Sean H" last="Adams">Sean H. Adams</name><name sortKey="Chintapalli, Sree V" sort="Chintapalli, Sree V" uniqKey="Chintapalli S" first="Sree V" last="Chintapalli">Sree V. Chintapalli</name><name sortKey="Chintapalli, Sree V" sort="Chintapalli, Sree V" uniqKey="Chintapalli S" first="Sree V" last="Chintapalli">Sree V. Chintapalli</name><name sortKey="Graham, James L" sort="Graham, James L" uniqKey="Graham J" first="James L" last="Graham">James L. Graham</name><name sortKey="Graham, James L" sort="Graham, James L" uniqKey="Graham J" first="James L" last="Graham">James L. Graham</name><name sortKey="Havel, Peter J" sort="Havel, Peter J" uniqKey="Havel P" first="Peter J" last="Havel">Peter J. Havel</name><name sortKey="Havel, Peter J" sort="Havel, Peter J" uniqKey="Havel P" first="Peter J" last="Havel">Peter J. Havel</name><name sortKey="Mercer, Kelly E" sort="Mercer, Kelly E" uniqKey="Mercer K" first="Kelly E" last="Mercer">Kelly E. Mercer</name><name sortKey="Mercer, Kelly E" sort="Mercer, Kelly E" uniqKey="Mercer K" first="Kelly E" last="Mercer">Kelly E. Mercer</name><name sortKey="Nookaew, Intawat" sort="Nookaew, Intawat" uniqKey="Nookaew I" first="Intawat" last="Nookaew">Intawat Nookaew</name><name sortKey="Piccolo, Brian D" sort="Piccolo, Brian D" uniqKey="Piccolo B" first="Brian D" last="Piccolo">Brian D. Piccolo</name><name sortKey="Shankar, Kartik" sort="Shankar, Kartik" uniqKey="Shankar K" first="Kartik" last="Shankar">Kartik Shankar</name><name sortKey="Shankar, Kartik" sort="Shankar, Kartik" uniqKey="Shankar K" first="Kartik" last="Shankar">Kartik Shankar</name><name sortKey="Stanhope, Kimber L" sort="Stanhope, Kimber L" uniqKey="Stanhope K" first="Kimber L" last="Stanhope">Kimber L. Stanhope</name><name sortKey="Stanhope, Kimber L" sort="Stanhope, Kimber L" uniqKey="Stanhope K" first="Kimber L" last="Stanhope">Kimber L. Stanhope</name><name sortKey="Wankhade, Umesh D" sort="Wankhade, Umesh D" uniqKey="Wankhade U" first="Umesh D" last="Wankhade">Umesh D. Wankhade</name><name sortKey="Wankhade, Umesh D" sort="Wankhade, Umesh D" uniqKey="Wankhade U" first="Umesh D" last="Wankhade">Umesh D. Wankhade</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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